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Methyl-CpG binding domain proteins (MBD proteins) and proteins that interact with methyl-CpG-binding proteins are involved in the complex process of transcription regulation. Specifically, methylated DNA binding proteins play a role in transcriptional repression by preventing the access of transcription factors to target sites. They close the chromatin structure by recruiting histone deacetylases (HDACs) and histone methyltransferases (HMTs) and are central to epigenetic studies.